CATCH

Proteolysis: Adaptor, Adaptor, Catch Me a Catch

The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.

Catch bonds

What has been your biggest error? Back at the beginning of this century, I used to say “I am going to spend the rest of my life trapped in a mitochondrion!”. This was because I was convinced that it was never going to be possible to retrieve even partial extinct genomes. Now, there are genomic sequences for many ancient humans and animals. This goes back to the famous Arthur C. Clarke quote: “W...

Statistics catch-up lecture

Example 1. In a genetic study, n = 2217 patients are recruited, among which 1127 have bladder cancer. After whole genome sequencing, p = 475290 single nucleatide polymorphisms (or SNPs, a possible variation of the DNA sequence at one location) are measured on each patient. We construct a matrix X = (Xij)1≤i≤n,1≤j≤p where Xij = 1 if the ith patient has a mutation at jth location and 0 otherwise....

To Catch a Predator

This paper is about moral panics over contemporary technology, which I call " technopanics. " I use two examples, the cyberporn panic of 1996 and the contemporary panic over online predators and MySpace, to demonstrate the links between media coverage and content legislation. In both cases, Internet content legislation is directly linked to media-fueled moral panics that concern uses of technol...

Catch-up Growth